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Article

Unexpected features of acute T lymphoblastic lymphomas in Notch1IC transgenic rats.

European journal of immunology - 1 Aug 2006

van den Brandt Jens, Kwon Soon-Hwan, McPherson Kirsty G, Petrovic Suzana, Zettl Andreas, Müller-Hermelink Hans Konrad, Reichardt Holger M

Abstract excerpt

Dysregulated Notch signaling accounts for the majority of acute T lymphoblastic leukemia/lymphoma (T-ALL) cases in humans. Here, we characterize lymphomas from Notch1IC transgenic rats, which develop T-ALL shortly after weaning, and show that they display a number of previously undocumented features. Starting from monoclonal thymic tumors, the CD4(+)CD8alphaalpha(+) lymphoma cells infiltrate the bone marrow and...

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Identifiers

PMID: 16838279
DOI: 10.1002/eji.200535791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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