Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Beta-catenin is dispensable for hematopoiesis and lymphopoiesis.

The Journal of experimental medicine - 19 Jan 2004

Cobas Monica, Wilson Anne, Ernst Bettina, Mancini Stéphane J C, MacDonald H Robson, Kemler Rolf, Radtke Freddy

Abstract excerpt

Beta-catenin-mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP-mediated inactivation of the beta-catenin gene in bone marrow progeni...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to beta Catenin
Share to Chimera

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoskeletal Proteins

Share to Hematopoiesis

Share to Integrases

Share to Lymphopoiesis

Share to Wnt Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 14718516
DOI: 10.1084/jem.20031615
PMCID: PMC2211763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14718516-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beta-catenin is dispensable for hematopoiesis and lymphopoiesis.PMID 14718516Read ↗

Role of beta-catenin in B cell development and function.Semantic proximity Read ↗

β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL.Semantic proximity Read ↗

β-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemiaSemantic proximity Read ↗

β-Catenin–TCF/LEF signaling promotes steady-state and emergency granulopoiesis via G-CSF receptor upregulationSemantic proximity Read ↗

Viable c-Kit(W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis.Semantic proximity Read ↗

Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling.Semantic proximity Read ↗

Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion.Semantic proximity Read ↗

Circulating hematopoietic progenitors with T lineage potential.Semantic proximity Read ↗

TGF-β type II receptor–deficient thymocytes develop normally but demonstrate increased CD8+ proliferation in vivoSemantic proximity Read ↗

Wnt/β-catenin regulates alloreactive T cells for the treatment of hematological malignanciesSemantic proximity Read ↗

beta-Catenin expression enhances generation of mature thymocytes.Semantic proximity Read ↗

Canonical Wnt Pathway Controls mESC Self-Renewal Through Inhibition of Spontaneous Differentiation via β-Catenin/TCF/LEF Functions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.