Article

TCF-1 in CD4 T cells regulates GVHD severity and persistence

2021-03-23

Abstract excerpt

Graft-versus-host disease (GVHD) is a leading cause of mortality following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Mature donor T cells in the graft mediate graft-versus-leukemia (GVL) responses against residual tumor cells, which may persist after pre-transplant conditioning regimens. Importantly, the same mature T cells also mediate GVHD. The transcription factor T Cell Factor-1 (TCF-1) i...

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Literature Corpus work: a37c765e-c256-54f8-91ec-e9d22228e46f
DOI: 10.1101/2021.03.22.436492

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