Article
Pyp3 PTPase acts as a mitotic inducer in fission yeast.
The EMBO journal - 1 Dec 1992
Millar J B, Lenaers G, Russell P
Abstract excerpt
The p34cdc2 M-phase kinase is regulated by inhibitory phosphorylation of Tyr15, largely through the actions of the p107wee1 tyrosine kinase and p80cdc25 protein tyrosine phosphatase (PTPase). In this study we demonstrate that a second PTPase, encoded by pyp3, also contributes to tyrosyl dephosphorylation of p34cdc2. Pyp3 was identified as a high copy suppressor of a cdc25- mutation. The pyp3 gene encodes a 33 kDa...
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