Article
Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase.
Science (New York, N.Y.) - 14 Dec 1990
Gould K L, Moreno S, Tonks N K, Nurse P
Abstract excerpt
The onset of M phase requires the activation of the pp34 protein kinase in all eukaryotes thus far examined. In Schizosaccharomyces pombe, pp34 is phosphorylated on Tyr15, and dephosphorylation of this residue regulates the initiation of mitosis. In this study, it is shown that dephosphorylation of Tyr15 triggered activation of the pp34-cyclin complex from fission yeast, that a human protein-tyrosine phosphatase...
Topics
- Cell Cycle Proteins
- Cyclins
- Enzyme Activation
- Fungal Proteins
- Humans
- Mitosis
- Mutation
- Phosphoprotein Phosphatases
- Phosphorylation
- Phosphotyrosine
- Protein Kinases
- Protein Tyrosine Phosphatases