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Article

F-box proteins Pof3 and Pof1 regulate Wee1 degradation and mitotic entry in fission yeast.

Journal of cell science - 2 Feb 2018

Qiu Cui, Yi Yuan-Yuan, Lucena Rafael, Wu Meng-Juan, Sun Jia-Hao, Wang Xi, Jin Quan-Wen, Wang Yamei

Abstract excerpt

The key cyclin-dependent kinase Cdk1 (Cdc2) promotes irreversible mitotic entry, mainly by activating the phosphatase Cdc25 while suppressing the tyrosine kinase Wee1. Wee1 needs to be downregulated at the onset of mitosis to ensure rapid activation of Cdk1. In human somatic cells, one mechanism of suppressing Wee1 activity is mediated by ubiquitylation-dependent proteolysis through the Skp1/Cul1/F-box protein...

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Source

Identifiers

PMID: 29361524
DOI: 10.1242/jcs.202895

Genes

CDCA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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F-box proteins Pof3 and Pof1 regulate Wee1 degradation and mitotic entry in fission yeast.PMID 29361524Read ↗

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