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Article

spo12 is a multicopy suppressor of mcs3 that is periodically expressed in fission yeast mitosis.

Molecular & general genetics : MGG - 1 Oct 2000

Samuel J M, Fournier N, Simanis V, Millar J B

Abstract excerpt

Hyperactivation of Cdc2 in fission yeast causes cells to undergo a lethal premature mitosis, a phenomenon called mitotic catastrophe. This phenotype is observed in cdc2-3w wee1-50 cells at high temperature and is suppressed by a single recessive mutant, mcs3-12. Mcs3 acts independently of the Wee1 kinase and Cdc25 phosphatase, two major regulators of Cdc2. We have isolated multicopy suppressors of the cell cycle...

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PMID: 11085271
DOI: 10.1007/s004380000324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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