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Article

Cleft palate, transforming growth factor alpha gene variants, and maternal exposures: assessing gene-environment interactions in case-parent triads.

Genetic epidemiology - 1 Dec 2003

Jugessur Astanand, Lie Rolv T, Wilcox Allen J, Murray Jeffrey C, Taylor Jack A, Saugstad Ola D, Vindenes Hallvard A, Abyholm Frank E

Abstract excerpt

We have previously reported a threefold risk of cleft palate only (CPO) among children homozygous for the less common allele A2 at the TaqI marker site of the transforming growth factor alpha gene (TGFA) (Jugessur et al. [2003a] Genet. Epidemiol. 24:230-239). Here we assess possible interaction between the child's TGFA TaqI A2A2 genotype and maternal cigarette smoking, alcohol consumption, use of multivitamins...

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Source

Identifiers

PMID: 14639706
DOI: 10.1002/gepi.10268

Genes

TGFA
CPO
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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