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Article

Exploring the effects of methylenetetrahydrofolate reductase gene variants C677T and A1298C on the risk of orofacial clefts in 261 Norwegian case-parent triads.

American journal of epidemiology - 15 Jun 2003

Jugessur Astanand, Wilcox Allen J, Lie Rolv T, Murray Jeffrey C, Taylor Jack A, Ulvik Arve, Drevon Christian A, Vindenes Hallvard A, Abyholm Frank E

Abstract excerpt

Folic acid and the methylenetetrahydrofolate reductase (MTHFR) gene have both been implicated in the etiology of orofacial clefts. The authors selected 261 case-parent triads (173 cases with cleft lip with or without cleft palate (CL/P) and 88 cases with cleft palate only (CPO)) from a Norwegian population-based study of orofacial clefts (May 1996-1998). A case-parent triad design was used to examine whether...

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Identifiers

PMID: 12796044
DOI: 10.1093/aje/kwg097

Genes

CPO
MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Exploring the effects of methylenetetrahydrofolate reductase gene variants C677T and A1298C on the risk of orofacial clefts in 261 Norwegian case-parent triads.PMID 12796044Read ↗

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