Article
Sum statistics for the joint detection of multiple disease loci in case-control association studies with SNP markers.
Genetic epidemiology - 1 Dec 2003
Wille Anja, Hoh Josephine, Ott Jurg
Abstract excerpt
In complex traits, multiple disease loci presumably interact to produce the disease. For this reason, even with high-resolution single nucleotide polymorphism (SNP) marker maps, it has been difficult to map susceptibility loci by conventional locus-by-locus methods. Fine mapping strategies are needed that allow for the simultaneous detection of interacting disease loci while handling large numbers of densely...
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