Article
sumSTAAR: A flexible framework for gene-based association studies using GWAS summary statistics.
PLoS computational biology - 1 Jun 2022
Belonogova Nadezhda M, Svishcheva Gulnara R, Kirichenko Anatoly V, Zorkoltseva Irina V, Tsepilov Yakov A, Axenovich Tatiana I
Abstract excerpt
Gene-based association analysis is an effective gene-mapping tool. Many gene-based methods have been proposed recently. However, their power depends on the underlying genetic architecture, which is rarely known in complex traits, and so it is likely that a combination of such methods could serve as a universal approach. Several frameworks combining different gene-based methods have been developed. However, they...
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