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Article

Molecular mechanism of terbinafine resistance in Saccharomyces cerevisiae.

Antimicrobial agents and chemotherapy - 1 Dec 2003

Leber Regina, Fuchsbichler Sandra, Klobucníková Vlasta, Schweighofer Natascha, Pitters Eva, Wohlfarter Kathrin, Lederer Mojca, Landl Karina, Ruckenstuhl Christoph, Hapala Ivan, Turnowsky Friederike

Abstract excerpt

Ten mutants of the yeast Saccharomyces cerevisiae resistant to the antimycotic terbinafine were isolated after chemical or UV mutagenesis. Molecular analysis of these mutants revealed single base pair exchanges in the ERG1 gene coding for squalene epoxidase, the target of terbinafine. The mutants did not show cross-resistance to any of the substrates of various pleiotropic drug resistance efflux pumps tested. The...

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Identifiers

PMID: 14638499
DOI: 10.1128/AAC.47.12.3890-3900.2003
PMCID: PMC296195

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Source receipt: pubmed, retrieved 7 Sept 2026.

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