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Amino Acid Substitution in<i>Trichophyton rubrum</i>Squalene Epoxidase Associated with Resistance to Terbinafine

25 Jun 2005

Abstract excerpt

There has only been one clinically confirmed case of terbinafine resistance in dermatophytes, where six sequential Trichophyton rubrum isolates from the same patient were found to be resistant to terbinafine and cross-resistant to other squalene epoxidase (SE) inhibitors. Microsomal SE activity from these resistant isolates was insensitive to terbinafine, suggesting a target-based mechanism of resistance (B....

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PMID: 15980358
DOI: 10.1128/aac.49.7.2840-2844.2005

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