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Article

Terbinafine resistance in a pleiotropic yeast mutant is caused by a single point mutation in the ERG1 gene.

Biochemical and biophysical research communications - 26 Sept 2003

Klobucníková Vlasta, Kohút Peter, Leber Regina, Fuchsbichler Sandra, Schweighofer Natascha, Turnowsky Friederike, Hapala Ivan

Abstract excerpt

A terbinafine-resistant mutant of the yeast Saccharomyces cerevisiae with a complex pleiotropic phenotype (resistance to terbinafine and itraconazole, sensitivity to several antifungal compounds, respiration deficiency, and temperature sensitivity) has been isolated after chemical mutagenesis. Detailed analysis revealed that some of its traits (thermosensitive growth, sensitivity to the polyene antimycotic...

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PMID: 12963042
DOI: 10.1016/j.bbrc.2003.08.051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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