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Article

Characterization of squalene epoxidase of Saccharomyces cerevisiae by applying terbinafine-sensitive variants.

Antimicrobial agents and chemotherapy - 1 Jan 2007

Ruckenstuhl Christoph, Lang Silvia, Poschenel Andrea, Eidenberger Armin, Baral Pravas Kumar, Kohút Peter, Hapala Ivan, Gruber Karl, Turnowsky Friederike

Abstract excerpt

Squalene epoxidase (SE) is the target of terbinafine, which specifically inhibits the fungal enzyme in a noncompetitive manner. On the basis of functional homologies to p-hydroxybenzoate hydroxylase (PHBH) from Pseudomonas fluorescens, the Erg1 protein contains two flavin adenine dinucleotide (FAD) domains and one nucleotide binding (NB) site. By in vitro mutagenesis of the ERG1 gene, which codes for the...

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Identifiers

PMID: 17043127
DOI: 10.1128/AAC.00988-06
PMCID: PMC1797698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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