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Article

Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice.

Cell - 31 Oct 2003

Lane Andrew A, Ley Timothy J

Abstract excerpt

The fusion protein PML-RARalpha, generated by the t(15;17)(q22;q11.2) translocation associated with acute promyelocytic leukemia (APL), initiates APL when expressed in the early myeloid compartment of transgenic mice. PML-RARalpha is cleaved in several positions by a neutral serine protease in a...

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Source

Identifiers

PMID: 14636558
DOI: 10.1016/s0092-8674(03)00852-3

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14636558-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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