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Article

Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.

Blood - 24 Feb 2011

Welch John S, Klco Jeffery M, Varghese Nobish, Nagarajan Rakesh, Ley Timothy J

Abstract excerpt

RARA (retinoic acid receptor alpha) haploinsufficiency is an invariable consequence of t(15;17)(q22;q21) translocations in acute promyelocytic leukemia (APL). Retinoids and RARA activity have been implicated in hematopoietic self-renewal and neutrophil maturation. We and others therefore predicted that RARA haploinsufficiency would contribute to APL pathogenesis. To test this hypothesis, we crossed Rara(+/-) mice...

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Source

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Identifiers

PMID: 21190992
DOI: 10.1182/blood-2010-08-300087
PMCID: PMC3317790

Genes

RARA
PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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