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Article

Evolution at a high imposed mutation rate: adaptation obscures the load in phage T7.

Genetics - 1 Jan 2010

Springman R, Keller T, Molineux I J, Bull J J

Abstract excerpt

Evolution at high mutation rates is expected to reduce population fitness deterministically by the accumulation of deleterious mutations. A high enough rate should even cause extinction (lethal mutagenesis), a principle motivating the clinical use of mutagenic drugs to treat viral infections. The...

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Share to Adaptation, Biological
Share to Bacteriophage T7

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Evolution, Molecular

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Source

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Identifiers

PMID: 19858285
DOI: 10.1534/genetics.109.108803
PMCID: PMC2815918

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19858285-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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