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Article

New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals

8 Jul 2015

Abstract excerpt

OBJECTIVES: We have previously identified a 115-gene signature that characterises the metastatic potential of human primary colon cancers. The signature included the canonical Wnt target gene BAMBI, which promoted experimental metastasis in mice. Here, we identified three new direct Wnt target genes from the signature, and studied their functions in epithelial-mesenchymal transition (EMT), cell migration and...

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PMID: 26156959
DOI: 10.1136/gutjnl-2014-307900

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