Article
Role of the fourth membrane domain of the NR2B subunit in the assembly of the NMDA receptor.
Channels (Austin, Tex.) - 1 Jan 2000
Horak Martin, Al-Hallaq Rana A, Chang Kai, Wenthold Robert J
Abstract excerpt
N-methyl-D-aspartate (NMDA) receptors play crucial roles in excitatory synaptic transmission as well as in excitotoxicity. A growing body of evidence suggests that the regulation of both subunit composition and the number of NMDA receptors reaching the surface membrane are tightly regulated. Recently, we have shown that the third membrane domains (M3) of both NR1 and NR2B subunits contain endoplasmic reticulum...
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