Article
AGAP3 and Arf6 regulate trafficking of AMPA receptors and synaptic plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Jul 2013
Oku Yuko, Huganir Richard L
Abstract excerpt
During NMDA receptor-mediated long-term potentiation (LTP), synapses are strengthened by trafficking AMPA receptors to the synapse through a calcium-dependent kinase cascade following activation of NMDA receptors. This process results in a long-lasting increase in synaptic strength that is thought to be a cellular mechanism for learning and memory. Over the past 20 years, many signaling pathways have been shown...
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