Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Test of synergistic interactions among deleterious mutations in bacteria.

Nature - 27 Nov 1997

Elena S F, Lenski R E

Abstract excerpt

Identifying the forces responsible for the origin and maintenance of sexuality remains one of the greatest unsolved problems in biology. The mutational deterministic hypothesis postulates that sex is an adaptation that allows deleterious mutations to be purged from the genome; it requires synergistic interactions, which means that two mutations would be more harmful together than expected from their separate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Directed Molecular Evolution
Share to Escherichia coli
Share to Genes, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Models, Genetic

Share to Mutagenesis, Insertional

Share to Mutation

Share to Recombination, Genetic

Source

Identifiers

PMID: 9389477
DOI: 10.1038/37108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Test of synergistic interactions among deleterious mutations in bacteria.PMID 9389477Read ↗

Epistasis between beneficial mutations and the phenotype-to-fitness Map for a ssDNA virus.Semantic proximity Read ↗

Mutation and sex in a competitive world.Semantic proximity Read ↗

The environment affects epistatic interactions to alter the topology of an empirical fitness landscape.Semantic proximity Read ↗

Analysis of epistatic interactions and fitness landscapes using a new geometric approach.Semantic proximity Read ↗

An experimental test for synergistic epistasis and its application in Chlamydomonas.Semantic proximity Read ↗

Evolution can favor antagonistic epistasis.Semantic proximity Read ↗

Dependence of epistasis on environment and mutation severity as revealed by in silico mutagenesis of phage t7.Semantic proximity Read ↗

Fitness effects of mutations in bacteria.Semantic proximity Read ↗

The Valley-of-Death: reciprocal sign epistasis constrains adaptive trajectories in a constant, nutrient limiting environment.Semantic proximity Read ↗

The genotypic view of social interactions in microbial communities.Semantic proximity Read ↗

Environment determines epistatic patterns for a ssDNA virus.Semantic proximity Read ↗

Defining genetic interaction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.