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Article

A pyrophosphatase regulating polyphosphate metabolism in acidocalcisomes is essential for Trypanosoma brucei virulence in mice.

The Journal of biological chemistry - 30 Jan 2004

Lemercier Guillaume, Espiau Benoit, Ruiz Felix A, Vieira Mauricio, Luo Shuhong, Baltz Theo, Docampo Roberto, Bakalara Norbert

Abstract excerpt

We report the functional characterization of a soluble pyrophosphatase (TbVSP1), which localizes to acidocalcisomes, a vesicular acidic compartment of Trypanosoma brucei. Depending on the pH and the cofactors Mg(2+) or Zn(2+), both present in the compartment, the enzyme hydrolyzes either inorganic pyrophosphate (PP(i)) (k(cat) = 385 s(-1)) or tripolyP (polyP(3)) and polyphosphate (polyP) of 28 residues...

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Identifiers

PMID: 14615483
DOI: 10.1074/jbc.M309974200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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