Article

Maintenance of pyrophosphate homeostasis in multiple subcellular compartments is essential in <i>Plasmodium falciparum</i>

2025-02-20

Abstract excerpt

Pyrophosphate is a byproduct of numerous cellular reactions that use ATP or other nucleoside triphosphates to synthesize DNA, RNA, protein, and other molecules. Its degradation into monophosphate is thus crucial for the survival and proliferation of all life forms. The human malaria parasite Plasmodium falciparum encodes two classes of pyrophosphatases to hydrolyze pyrophosphate. The first consists of P. falcipa...

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Literature Corpus work: 7ac74753-6cc6-5a6e-bffc-1e2a3c1627f7
DOI: 10.1101/2025.02.20.639246

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