Article

<i>Trypanosoma brucei</i> Tim50 Plays a Critical Role in Cell Cycle Regulation and Parasite Infectivity

2021-04-27

Abstract excerpt

Tim50 is a receptor subunit of the preprotein-translocase of the mitochondrial inner membrane, TIM23. Trypanosoma brucei , the infective agent for African trypanosomiasis, possesses a homologue of Tim50 (TbTim50) with a pair of characteristic DXDX(T/V) phosphatase signature motifs. Here, we demonstrated that besides its protein phosphatase activity, the recombinant TbTim50 binds and hydrolyzes phosphatidic acid i...

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Literature Corpus work: 8c15dd44-38e5-5b64-98a9-c4fe8c4d2b99
DOI: 10.1101/2021.04.26.441502

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