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Article

Essential role of pyrophosphate homeostasis mediated by the pyrophosphate-dependent phosphofructokinase in Toxoplasma gondii.

PLoS pathogens - 1 Feb 2022

Yang Xuke, Yin Xiaoyan, Liu Jiaojiao, Niu Zhipeng, Yang Jichao, Shen Bang

Abstract excerpt

Many biosynthetic pathways produce pyrophosphate (PPi) as a by-product, which is cytotoxic if accumulated at high levels. Pyrophosphatases play pivotal roles in PPi detoxification by converting PPi to inorganic phosphate. A number of apicomplexan parasites, including Toxoplasma gondii and Cryptosporidium parvum, express a PPi-dependent phosphofructokinase (PPi-PFK) that consumes PPi to power the phosphorylation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35104280
DOI: 10.1371/journal.ppat.1010293
PMCID: PMC8836295

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