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Article

Intracellular formation of "undisruptable" dimers of inducible nitric oxide synthase.

Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 2003

Kolodziejski Pawel J, Rashid Mohammad B, Eissa N Tony

Abstract excerpt

Overproduction of nitric oxide (NO) by inducible NO synthase (iNOS) has been implicated in the pathogenesis of many diseases. iNOS is active only as a homodimer. Dimerization of iNOS represents a potentially critical target for therapeutic intervention. In this study, we show that intracellular iNOS forms dimers that are "undisruptable" by boiling, denaturants, or reducing agents. Undisruptable (UD) dimers are...

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Identifiers

PMID: 14614131
DOI: 10.1073/pnas.2435290100
PMCID: PMC283580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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