Article

<i>N</i> -chlorination mediates protective and immunomodulatory effects of oxidized human plasma proteins

2019-03-23

Abstract excerpt

<h4>ABSTRACT</h4> Hypochlorous acid (HOCl), a powerful antimicrobial oxidant, is produced by neutrophils to fight infections. Here we show that N -chlorination, induced by HOCl concentrations encountered at sites of inflammation, converts blood plasma proteins into chaperone-like holdases that protect other proteins from aggregation. This chaperone-like conversion was reversible by antioxidants and was abrogated...

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Literature Corpus work: b18af346-3dac-5258-b51e-90e5414c4917
DOI: 10.1101/584961

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