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Article

Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration.

Cell reports - 30 Mar 2021

Yi Weiwei, Zhang Yuying, Liu Bo, Zhou Yuanyuan, Liao Dandan, Qiao Xinhua, Gao Dan, Xie Ting, Yao Qin, Zhang Yao, Qiu Yugang, Huang Gang, Chen Zhiyang, Chen Chang, Ju Zhenyu

Abstract excerpt

Hematopoietic stem cells (HSCs) regenerate blood cells upon hematopoietic injuries. During homeostasis, HSCs are maintained in a low reactive oxygen species (ROS) state to prevent exhaustion. However, the role of nitric oxide (NO) in controlling HSC regeneration is still unclear. Here, we find increased NO during HSC regeneration with an accumulation of protein aggregation. S-nitrosoglutathione reductase...

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Identifiers

PMID: 33789111
DOI: 10.1016/j.celrep.2021.108922
PMCID: PMC9204508

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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