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Article

Inter-isoformal regulation of nitric oxide synthase through heteromeric dimerization.

Biochimica et biophysica acta - 14 Oct 1998

Watanabe Y, Nishio M, Hamaji S, Hidaka H

Abstract excerpt

Biochemical characterization of neuronal nitric oxide synthase (nNOS) has demonstrated a unique complexity with the native protein being a homodimer. To cast light on its enzyme structure-activity relationship, inactive nNOS, generated by mutation of (Lys732-Lys-Leu) to (Asp732-Asp-Glu) (Watanabe et al., FEBS Lett., 403 (1997) 75-78), and active nNOS were co-expressed using the Sf9 and COS-7 cell expression...

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PMID: 9774731
DOI: 10.1016/s0167-4838(98)00191-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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