Inter-isoformal regulation of nitric oxide synthase through heteromeric dimerization.

doi:10.1016/s0167-4838(98)00191-5

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Article

Inter-isoformal regulation of nitric oxide synthase through heteromeric dimerization.

Biochimica et biophysica acta - 14 Oct 1998

Watanabe Y, Nishio M, Hamaji S, Hidaka H

Abstract excerpt

Biochemical characterization of neuronal nitric oxide synthase (nNOS) has demonstrated a unique complexity with the native protein being a homodimer. To cast light on its enzyme structure-activity relationship, inactive nNOS, generated by mutation of (Lys732-Lys-Leu) to (Asp732-Asp-Glu) (Watanabe...

Topics

Animals
COS Cells
Calcium
Calmodulin
Dimerization
Electrophoresis, Polyacrylamide Gel
Isoenzymes
Mutation
Neurons
Nitric Oxide Synthase
Oligonucleotides
Polymerase Chain Reaction
Structure-Activity Relationship
Transfection

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