Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis

Abstract excerpt

Nuclear Factor-kappaB (NF-kappaB) is a major transcription regulator of immune response, apoptosis and cell-growth control genes, and is upregulated in inflammatory bowel disease (IBD), both ulcerative colitis (UC) and Crohn's disease. The NFKB1 gene encodes the NF-kappaB p105/p50 isoforms. Genome-wide screens in IBD families show evidence for linkage on chromosome 4q where NFKB1 maps. We sequenced the NFKB1...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Helicobacter pylori-related gastroenterology studies
• Share to Inflammatory Bowel Disease
• Share to NF-κB Signaling Pathways