Article
A NFKB1 promoter polymorphism is involved in susceptibility to ulcerative colitis.
International journal of immunogenetics - 1 Dec 2005
Borm M E A, van Bodegraven A A, Mulder C J J, Kraal G, Bouma G
Abstract excerpt
Nuclear factor kappaB (NF-kappaB) designates a group of critical transcription factors involved in a variety of immunologic and/or inflammatory processes. Conceivably, genes involved in the NF-kappaB pathway make interesting candidate genes for chronic inflammatory disorders, including the inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC). In two mouse models of colitis, strong...
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