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Article

Mechanism of Csk-mediated down-regulation of Src family tyrosine kinases in epidermal growth factor signaling.

The Journal of biological chemistry - 13 Feb 2004

Matsuoka Hidetada, Nada Shigeyuki, Okada Masato

Abstract excerpt

The Src family tyrosine kinases (SFKs) play pivotal roles as molecular switches that link a variety of extracellular cues to intracellular signaling pathway. The function of SFK is regulated by phosphorylation at the C-terminal regulatory site mediated by Csk. Recently a novel SFK target Cbp (or PAG) was identified as a membrane-anchored scaffold protein for Csk. To establish the mechanism of Csk/Cbp-mediated...

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Source

Identifiers

PMID: 14613929
DOI: 10.1074/jbc.M311278200

Genes

CFP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mechanism of Csk-mediated down-regulation of Src family tyrosine kinases in epidermal growth factor signaling.PMID 14613929Read ↗

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