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Article

The RING finger domain of Cbl is essential for negative regulation of the Syk tyrosine kinase.

The Journal of biological chemistry - 7 Jan 2000

Ota S, Hazeki K, Rao N, Lupher M L, Andoniou C E, Druker B, Band H

Abstract excerpt

The proto-oncogene product Cbl has emerged as a negative regulator of a number of protein-tyrosine kinases, including the ZAP-70/Syk tyrosine kinases that are critical for signaling in hematopoietic cells. The evolutionarily conserved N-terminal tyrosine kinase-binding domain is required for Cbl to associate with ZAP-70/Syk and for their subsequent negative regulation. However, the role of the remaining...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10617633
DOI: 10.1074/jbc.275.1.414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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