Article
C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases.
The Journal of biological chemistry - 3 Nov 2006
Chong Yuh-Ping, Chan Andrew S, Chan Khai-Chew, Williamson Nicholas A, Lerner Edwina C, Smithgall Thomas E, Bjorge Jeffrey D, Fujita Donald J, Purcell Anthony W, Scholz Glen, Mulhern Terrence D, Cheng Heung-Chin
Abstract excerpt
The Src family of protein kinases (SFKs) mediates mitogenic signal transduction, and constitutive SFK activation is associated with tumorigenesis. To prevent constitutive SFK activation, the catalytic activity of SFKs in normal mammalian cells is suppressed mainly by two inhibitors called C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK), which inactivate SFKs by phosphorylating a consensus tyrosine...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Catalysis
- Cell Line
- Down-Regulation
- Enzyme Activation
- Humans
- Mutation
- Protein Binding
- Protein Conformation
- Spodoptera
- src-Family Kinases