Article
Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine.
Cell communication and signaling : CCS - 7 Aug 2017
Advani Gahana, Lim Ya Chee, Catimel Bruno, Lio Daisy Sio Seng, Ng Nadia L Y, Chüeh Anderly C, Tran Mai, Anasir Mohd Ishtiaq, Verkade Heather, Zhu Hong-Jian, Turk Benjamin E, Smithgall Thomas E, Ang Ching-Seng, Griffin Michael, Cheng Heung-Chin
Abstract excerpt
BACKGROUND: C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inhibitors of Src-family kinases (SFKs). They employ two mechanisms to inhibit SFKs. First, they phosphorylate the C-terminal tail tyrosine which stabilizes SFKs in a closed inactive conformation by engaging the SH2 domain in cis. Second, they employ a non-catalytic inhibitory mechanism involving direct binding of Csk...
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