Article
End resection initiates genomic instability in the absence of telomerase.
Molecular and cellular biology - 1 Dec 2003
Hackett Jennifer A, Greider Carol W
Abstract excerpt
Telomere dysfunction causes genomic instability. However, the mechanism that initiates this instability when telomeres become short is unclear. We measured the mutation rate and loss of heterozygosity along a chromosome arm in diploid yeast that lacked telomerase to distinguish between mechanisms for the initiation of instability. Sequence loss was localized near chromosome ends in the absence of telomerase but...
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