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Article

p190A inactivating mutations cause aberrant RhoA activation and promote malignant transformation via the Hippo-YAP pathway in endometrial cancer.

Signal transduction and targeted therapy - 27 May 2020

Wen Xiaoli, Wan Jing, He Qizhi, Wang Mengfei, Li Shuangdi, Jiang Mei, Qian Zhen, Liu Binya, Lu Wen, Wang Kai, Gao Kun, Wan Xiaoping

Abstract excerpt

The Rho family of GTPases is strictly regulated by a large family of GTPase-activating proteins (GAPs) that stimulate the relatively weak intrinsic GTP-hydrolyzing activity of Rho GTPases. p190A is a potent and widely expressed GAP that acts on RhoA GTPases. p190A is frequently mutated in endometrial cancer, but the contribution of p190A mutations to endometrial tumorigenesis remains unclear. Here we identified...

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Identifiers

PMID: 32457342
DOI: 10.1038/s41392-020-0170-6
PMCID: PMC7250911

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p190A inactivating mutations cause aberrant RhoA activation and promote malignant transformation via the Hippo-YAP pathway in endometrial cancer.PMID 32457342Read ↗

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