Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive.

doi:10.1016/j.jmb.2003.09.031

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Article

Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive.

Journal of molecular biology - 21 Nov 2003

Modesti Mauro, Junop Murray S, Ghirlando Rodolfo, van de Rakt Mandy, Gellert Martin, Yang Wei, Kanaar Roland

Abstract excerpt

The XRCC4 protein is of critical importance for the repair of broken chromosomal DNA by non-homologous end joining (NHEJ). The absence of XRCC4 abolishes chromosomal NHEJ almost completely. One reason for this severe phenotype is that XRCC4 binds and modulates the stability and activity of the NHEJ-specific ligase, DNA ligase IV. XRCC4 in solution is in equilibrium between the dimeric and tetrameric forms....

Topics

Animals
CHO Cells
Cricetinae
DNA
DNA Ligase ATP
DNA Ligases
DNA Repair
DNA-Binding Proteins
Gene Rearrangement
Humans
Mutation
Radiation, Ionizing

Source

Open in PubMed

Identifiers

PMID: 14607114
DOI: 10.1016/j.jmb.2003.09.031

Genes

XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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