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Article

C-Terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin.

Biochemical and biophysical research communications - 20 Sept 2013

Liu Sicheng, Liu Xunyue, Kamdar Radhika Pankaj, Wanotayan Rujira, Sharma Mukesh Kumar, Adachi Noritaka, Matsumoto Yoshihisa

Abstract excerpt

DNA ligase IV (LIG4) and XRCC4 form a complex to ligate two DNA ends at the final step of DNA double-strand break (DSB) repair through non-homologous end-joining (NHEJ). It is not fully understood how these proteins are recruited to DSBs. We recently demonstrated radiation-induced chromatin binding of XRCC4 by biochemical fractionation using detergent Nonidet P-40. In the present study, we examined the role of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

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Share to Protein Structure, Tertiary

Source

Identifiers

PMID: 23994631
DOI: 10.1016/j.bbrc.2013.08.068

Genes

LIG4
XRCC4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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