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Article

XRCC4's interaction with XLF is required for coding (but not signal) end joining.

Nucleic acids research - 1 Feb 2012

Roy Sunetra, Andres Sara N, Vergnes Alexandra, Neal Jessica A, Xu Yao, Yu Yaping, Lees-Miller Susan P, Junop Murray, Modesti Mauro, Meek Katheryn

Abstract excerpt

XRCC4 and XLF are structurally related proteins important for DNA Ligase IV function. XRCC4 forms a tight complex with DNA Ligase IV while XLF interacts directly with XRCC4. Both XRCC4 and XLF form homodimers that can polymerize as heterotypic filaments independently of DNA Ligase IV. Emerging structural and in vitro biochemical data suggest that XRCC4 and XLF together generate a filamentous structure that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22228831
DOI: 10.1093/nar/gkr1315
PMCID: PMC3287172

Genes

XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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XRCC4's interaction with XLF is required for coding (but not signal) end joining.PMID 22228831Read ↗

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