Article
Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability.
Proceedings of the National Academy of Sciences of the United States of America - 8 Feb 2022
Hodson Charlotte, Low Jason K K, van Twest Sylvie, Jones Samuel E, Swuec Paolo, Murphy Vincent, Tsukada Kaima, Fawkes Matthew, Bythell-Douglas Rohan, Davies Adelina, Holien Jessica K, O'Rourke Julienne J, Parker Benjamin L, Glaser Astrid, Parker Michael W, Mackay Joel P, Blackford Andrew N, Costa Alessandro, Deans Andrew J
Abstract excerpt
The RecQ-like helicase BLM cooperates with topoisomerase IIIα, RMI1, and RMI2 in a heterotetrameric complex (the "Bloom syndrome complex") for dissolution of double Holliday junctions, key intermediates in homologous recombination. Mutations in any component of the Bloom syndrome complex can cause genome instability and a highly cancer-prone disorder called Bloom syndrome. Some heterozygous carriers are also...
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