Article
The structural basis for partitioning of the XRCC1/DNA ligase III-α BRCT-mediated dimer complexes.
Nucleic acids research - 1 Sept 2011
Cuneo Matthew J, Gabel Scott A, Krahn Joseph M, Ricker Melissa A, London Robert E
Abstract excerpt
The ultimate step common to almost all DNA repair pathways is the ligation of the nicked intermediate to form contiguous double-stranded DNA. In the mammalian nucleotide and base excision repair pathways, the ligation step is carried out by ligase III-α. For efficient ligation, ligase III-α is constitutively bound to the scaffolding protein XRCC1 through interactions between the C-terminal BRCT domains of each...
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