Article
Alleles carried at positions -819 and -592 of the IL10 promoter affect transcription following stimulation of peripheral blood cells with Streptococcus pneumoniae.
Immunogenetics - 1 Dec 2003
Temple Suzanna E L, Lim Esther, Cheong Karey Y, Almeida Coral-Ann M, Price Patricia, Ardlie Kristin G, Waterer Grant W
Abstract excerpt
IL-10 inhibits the production of many pro-inflammatory cytokines. Polymorphisms in the IL10 gene promoter at positions -1082G-->A, -819C-->T and -592C-->A occur as three haplotypes, ATA, GCC and ACC. These influence several infectious and inflammatory diseases including community-acquired pneumonia, where a role for IL-10 is suggested by fluctuations in plasma levels of the cytokine. However, the effects of the...
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