Involvement of IL-10 gene promoter polymorphisms in the susceptibility for childhood asthma.

doi:10.1007/s00408-011-9312-5

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Article

Involvement of IL-10 gene promoter polymorphisms in the susceptibility for childhood asthma.

Lung - 1 Oct 2011

Kim Kyung Won, Lee Kyung Eun, Hong Jung Yeon, Kim Mi Na, Heo Won Il, Sohn Myung Hyun, Kim Kyu-Earn

Abstract excerpt

Asthma and atopy have a complex background that may result from the interaction of genes and the environment. Interleukin (IL)-10 is known to play various roles in immune-regulating and anti-inflammatory responses. The aim of this study was to evaluate the possible effect of the IL-10 promoter polymorphisms on susceptibility to childhood asthma. We recruited 333 patients with atopic asthma, 55 with nonatopic...

Topics

Adolescent
Asthma
Child
Eosinophil Cationic Protein
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Haplotypes
Humans
Interleukin-10
Male
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Promoter Regions, Genetic

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PMID: 21779975
DOI: 10.1007/s00408-011-9312-5

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