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Article

The interleukin-10-1082 G/A polymorphism: allele frequency in different populations and functional significance.

Cellular and molecular life sciences : CMLS - 1 Mar 2002

Rees L E N, Wood N A P, Gillespie K M, Lai K N, Gaston K, Mathieson P W

Abstract excerpt

Genotypic variation in the human interleukin-10 (IL-10) promoter may account for marked inter-individual variation in IL-10 production and may influence susceptibility to autoimmune diseases. The G/A polymorphism at position -1082 has been linked to high/low IL-10 producer status. We directly tested the functional significance of this polymorphism using DNA-binding assays and reporter gene assays, examined allele...

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Identifiers

PMID: 11964134
DOI: 10.1007/s00018-002-8448-0
PMCID: PMC11337416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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