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Article

Pneumococcal septic shock is associated with the interleukin-10-1082 gene promoter polymorphism.

American journal of respiratory and critical care medicine - 15 Aug 2003

Schaaf Bernhard M, Boehmke Florian, Esnaashari Hamed, Seitzer Ulrike, Kothe Henning, Maass Matthias, Zabel Peter, Dalhoff Klaus

Abstract excerpt

Polymorphisms in the tumor necrosis factor and interleukin-10 genes, linked to cytokine inducibility, may influence the inflammatory response to infection. We studied the biallelic interleukin-10-1082 promoter, the tumor necrosis factor-alpha-308 promoter, and the lymphotoxin-alpha polymorphisms with regard to the development of septic shock in pneumococcal infection. Sixty-nine patients with pneumococcal disease...

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Source

Identifiers

PMID: 12746253
DOI: 10.1164/rccm.200210-1164OC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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