Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Error catastrophe in mutant mitochondria.

Science of aging knowledge environment : SAGE KE - 13 Nov 2002

Hoopes Laura L Mays

Abstract excerpt

The error catastrophe theory of aging, proposed by Orgel in 1963, predicted a decrease in the fidelity of information transfer that accelerated as aging progressed, until properly functioning macromolecules could no longer be reliably made. The theory was extensively tested by comparing DNA polymerases, transfer RNAs, and proteins derived from aging versus young animals, but it did not prove to have general...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to DNA
Share to DNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Mitochondrial

Share to DNA Polymerase gamma

Share to Mitochondria

Share to Ophthalmoplegia, Chronic Progressive External

Source

Identifiers

PMID: 14603013
DOI: 10.1126/sageke.2002.45.vp6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Error catastrophe in mutant mitochondria.PMID 14603013Read ↗

Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases.Semantic proximity Read ↗

Somatic mitochondrial DNA mutations in mammalian aging.Semantic proximity Read ↗

Mutation and catastrophe in the aging genome.Semantic proximity Read ↗

Transcript errors generate a continuous stream of amyloid and prion-like proteins in human cellsSemantic proximity Read ↗

Intrinsic errors in mitochondrial translation trigger a decline in cell fitnessSemantic proximity Read ↗

On the relevance of mitochondrial fusions for the accumulation of mitochondrial deletion mutants: a modelling study.Semantic proximity Read ↗

Transcript errors generate amyloid-like proteins in huwman cells.Semantic proximity Read ↗

Running on empty: does mitochondrial DNA mutation limit replicative lifespan in yeast?: Mutations that increase the division rate of cells lacking mitochondrial DNA also extend replicative lifespan in Saccharomyces cerevisiae.Semantic proximity Read ↗

Modeling aging and retinal degeneration with mitochondrial DNA mutation burdenSemantic proximity Read ↗

Increased levels of RNA oxidation enhance the reversion frequency in aging pro-apoptotic yeast mutants.Semantic proximity Read ↗

The hidden costs of imperfection: transcription errors in protein aggregation diseases.Semantic proximity Read ↗

Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.