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Article

Increased levels of RNA oxidation enhance the reversion frequency in aging pro-apoptotic yeast mutants.

Apoptosis : an international journal on programmed cell death - 1 Feb 2017

Stirpe Mariarita, Palermo Vanessa, Ferrari Matteo, Mroczek Seweryn, Kufel Joanna, Falcone Claudio, Mazzoni Cristina

Abstract excerpt

Despite recent advances in understanding the complexity of RNA processes, regulation of the metabolism of oxidized cellular RNAs and the mechanisms through which oxidized ribonucleotides affect mRNA translation, and consequently cell viability, are not well characterized. We show here that the level of oxidized RNAs is markedly increased in a yeast decapping Kllsm4Δ1 mutant, which accumulates mRNAs, ages much...

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Identifiers

PMID: 27803986
DOI: 10.1007/s10495-016-1319-1
PMCID: PMC5306349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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