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Article

Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age.

PloS one - 1 Jan 2014

Wang Wei, Scheffler Katja, Esbensen Ying, Strand Janne M, Stewart James B, Bjørås Magnar, Eide Lars

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations can result in mitochondrial dysfunction, but emerging experimental data question the fundamental role of mtDNA mutagenesis in age-associated mitochondrial impairment. The multicopy nature of mtDNA renders the impact of a given mtDNA mutation unpredictable. In this study, we compared mtDNA stability and mtRNA integrity during normal aging. Seven distinct sites in mouse brain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24819950
DOI: 10.1371/journal.pone.0096940
PMCID: PMC4018447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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